CD163 anticorps (AA 1001-1121) (PE)

N° du produit ABIN741580

Cet anticorps Lapin Polyclonal détecte spécifiquement CD163 dans WB et FACS. Il présente une réactivité envers Humain, Souris, Rat, Porc et Chien.

Aperçu rapide pour CD163 anticorps (AA 1001-1121) (PE) (ABIN741580)

Antigène: CD163

Reactivité: Humain, Souris, Rat, Porc, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD163 est conjugé à/à la PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-CD163 anticorps (PE)

Épitope: AA 1001-1121

Réactivité croisée: Chien, Humain, Souris, Porc, Rat

Homologie: Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CD163/M130

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CD163

Antigène: CD163

Autre désignation: CD163/M130

Sujet:

Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Poids moléculaire: 130kDa

ID gène: 9332

UniProt: Q86VB7